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A single fluorophore to address multiple logic gates

机译:单个荧光团可处理多个逻辑门

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摘要

Logic gates with different radixes have been constructed using a biologically active molecule, 2-(4'-N, N-dimethylaminophenyl)imidazo[4,5-b]pyridine (DMAPIP-b). Taking advantage of the multiple binding sites of the fluorophore, a series of different molecular logic gates are developed using fluorescence intensities at different wavelengths. The high emission of the molecule is drastically quenched in the presence of Fe3+. It is regained by the addition of an equivalent amount of F-. The fluorescence On-Off nature has been used to construct molecular full subtractor and molecular keypad lock system with Boolean logic. A ternary system is generated by considering three defined fluorescence intensities at particular wavelengths. The smooth dependency of emission intensities with analyte concentration is utilized to construct an infinite-valued fuzzy logic system. The fuzzy logic system is further coupled with a neuroadaptation method to predict more accurately the dependency of molecular intensity on external inputs.
机译:已使用生物活性分子2-(4'-N,N-二甲基氨基苯基)咪唑并[4,5-b]吡啶(DMAPIP-b)构建了具有不同基数的逻辑门。利用荧光团的多个结合位点,利用不同波长的荧光强度开发了一系列不同的分子逻辑门。在Fe3 +的存在下,分子的高发射被彻底淬灭。通过添加等量的F-可以重新获得它。荧光开-关特性已被用于构建具有布尔逻辑的分子全减法器和分子键盘锁系统。通过考虑特定波长下的三个定义的荧光强度来生成三元系统。利用发射强度与分析物浓度之间的平滑关系来构建无限值模糊逻辑系统。模糊逻辑系统还与神经适应方法相结合,可以更准确地预测分子强度对外部输入的依赖性。

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