RELATIVE STEREOCHEMISTRY OF PINNATOXIN A, A POTENT SHELLFISH POISON FROM PINNA MURICATA

摘要

Pinnatoxin A, the principal toxin isolated from Pinna muricata, is a novel amphoteric macrocyclic compound composed of a 6,7-spiro ring, a 5,6-bicyclo ring and a 6,5,6-trispiroketal ring involving 14 chiral centers. The relative stereochemistry was deduced based on detailed analysis of NOESY and ROESY data, and (3)J(H-H) coupling constants. (C) 1996 Elsevier Science Ltd. [References: 10]