BIOMIMETIC TOTAL SYNTHESIS OF THE ACAT INHIBITOR (+)-PYRIPYROPENE E

摘要

The acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (+)-pyripyropene E (1) has been synthesized from famesyl acetate (9 steps, 9.6% overall yield). The convergent and stereoselective route exploited a biomimetic polyene cyclization as the key transformation. Copyright (C) 1996 Elsevier Science Ltd [References: 26]