CATALYTIC ASYMMETRIC CARBONYL-ENE REACTIONS WITH ALKYNYLOGOUS AND VINYLOGOUS GLYOXYLATES - APPLICATION TO CONTROLLED SYNTHESIS OF CHIRAL ISOCARBACYCLIN ANALOGUES

摘要

The asymmetric carbonyl-ene reaction with alkynylogous and vinylogous glyoxylates (1, 2) catalyzed by a binaphthol-derived chiral titanium complex is described. The catalytic asymmetric ene reaction with aldehyde (I) can be applied to the double asymmetric synthesis of isocarbacyclin analogues bearing a 2-allenyl side chain. Copyright (C) 1996 Elsevier Science Ltd [References: 35]