HIGHLY EFFICIENT SYNTHESIS OF PROPARGYL- AND ALLENYLTITANIUM REAGENTS FROM PROPARGYL HALIDES OR PROPARGYL ALCOHOL DERIVATIVES - PRACTICAL SYNTHESIS OF ALLENYL AND HOMOPROPARGYL ALCOHOLS

摘要

Reaction of Ti(O-i-Pr)(4) / 2 i-PrMgBr, synthetic equivalent of practical Ti(II) reagent, with propargyl halides or propargyl alcohol derivatives affords allenyl titanium compounds in excellent yields, thus providing an efficient and practical method for synthesis of both allenyl and homopropargyl alcohols by the successive treatment with aldehydes or ketones. [References: 11]