AMINO ACID DERIVED THIANE OXIDE AND DIOXIDE SYSTEMS AS DISPOSABLE TEMPLATES - SYNTHESIS OF ALPHA-AMINO KETONES, ANTI-AMINO ALCOHOLS AND AN AMINO CYCLOPENTENONE

摘要

Sulfones and sulfoxides synthesised from methionine and homocysteine thiolactone have been cyclised to amino ketones using potassium bis(trimethylsilyl)amide. Ramberg-Backlund chemistry on one of the sulfones gave an amino cyclopentenone whereas acyclic alpha-amino ketones and anti-amino alcohols were obtained by Raney nickel desulfurisation of the sulfoxides. Copyright (C) 1996 Elsevier Science Ltd [References: 16]