1-[2-(TRIMETHYLSILYL)ETHOXY]ETHYL (SEE) - A NOVEL HYBRID HYDROXY-PROTECTING GROUP BETWEEN 1-(ETHOXY)ETHYL (EE) AND 2-(TRIMETHYLSILYL)ETHOXYMETHYL (SEM)

摘要

The highly versatile 1-[(2-trimethylsilyl)ethoxy]ethyl (SEE) group, readily obtainable from an alcohol and 2-(trimethylsilyl)ethyl vinyl ether in the presence of a catalytic amount of PPTS, has been developed for the protection of hydroxyl groups. Its deprotection can be achieved under virtually neutral conditions with the use of a fluoride ion source, thus allowing for effective protection of hydroxyl groups of compounds that contain acid- and/or base-sensitive functional groups. Copyright (C) 1996 Elsevier Science Ltd. [References: 17]