ENANTIOSPECIFIC SYNTHESIS OF ALPHA-AMINO KETONES AND BETA-AMINO ALCOHOLS FROM THE REACTION OF N-(9-PHENYLFLUOREN-9-YL)-ALANINE OXAZOLIDINONE WITH ORGANOLITHIUM REAGENTS

摘要

Enantiomerically pure N-(9-phenylfluoren-9-yl) alpha-amino ketones were prepared by reaction of the N-Pf-alanine-derived oxazolidinone with organolithium reagents. alpha-Amino ketones thus obtained could be stereoselectively reduced to the corresponding syn or anti beta-amino alcohols depending upon the nature of the reducing agent. (C) 1996 Elsevier Science Ltd [References: 17]