Synthetic studies of N-reverse prenylated indole.Anefficient synthesis of antifungal indole alkaloids and N-reverse prenylated tryptophan

摘要

The efficient method for the synthesis of N-1,1-dimethyl-2-propenyl (reverse prenyl)indole was developed by the N-propargylation of the indoline,partial hydrogenation of the terminal alkyne,and oxidation to the indole using chemical manganese doxide (CMD).This method was used for the synthesis of the antifungal idole alkaloids 2,3,andN-reverse prenylated tryptophan.