Synthesis of notoamide J: A potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids

摘要

An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein. Starting from l-proline and a substituted tryptophan derivative, this synthesis also employs an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.