THE STEREOSELECTIVE HORNER-WITTIG REACTION WITH PHOSPHINE OXIDES - SYNTHESIS OF HINDERED Z ALKENES VIA LUCHE REDUCTION

摘要

The natural anti selectivity of the Homer-Wittig reaction with phosphine oxides is reduced when there is a branched chain next to the new C=C double bond. A better approach is Luche reduction of the corresponding ketones which gives high anti selectivity when the branched chain is placed on the side chain next to the phosphine oxide. [References: 23]