Zeolite-catalyzed acylation of heterocyclic compounds - VI. One-step synthesis of 3(benzofuran-2-carbonyl)pentane-2,4-dione from 2-acetylbenzofuran over HY-zeolite.

摘要

The reaction between 2-acetylbenzofuran and acetic anhydride at 60 degrees C in the presence of HY-zeolite (Si/Al = 16) led to a single final product:3-(benzofuran-2-carbonyl)pentane-2,4-dione resulting from two consecutive acylation steps on the side chain. It was obtained in a 90% purity at around 50% conversion of 2-acetylbenzofuran. Other minor products and intermediates were also identified. A mechanism is proposed to account for the formation of the various products. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 21]