HETEROCYCLIC COMPOUND CONTAINING A CARBINOL COMPONENT LINKED VIA A HETEROCYCLIC LINKER TO AN IMIDAZOLIDINE 2,4-DIONE COMPONENT AND ITS USE AS A LIVER RECEPTOR AGONIST

摘要

It is to provide a novel LXR.beta. agonist useful as a preventative and/ortherapeuticagent for atherosclerosis; arteriosclerosis such as those resulting fromdiabetes;dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatorydiseases that arecaused by inflammatory cytokines; skin diseases such as allergic skindiseases; diabetes;or Alzheimer's disease. It is a carbinol compound represented by the followinggeneralformula (I) or salt thereof, or their solvate:(see formula I)(wherein, each V and W independently show N or C-R7 ; each X and Yindependentlyshow CH2, C=O, SO2, etc.; Z shows CH or N; each R1, R2 and R7 independentlyshow ahydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows anoptionallysubstituted C6-10 aryl group or an optionally substituted 5- to 11-memberedheterocyclicgroup; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chainoptionallysubstituted with an oxo group, etc.; and n shows any integer of 0 to 2.)