A thiazine-S-oxide,Staudinger/aza-Wittig based synthesis of bezodiazepines and benzopthiadiazepines

摘要

A new approach to the synthesis of imine containing 1,2,5-benzothiadiazepine-1,1-dioxides and 1,4-benzodiazepin-5-ones using iminophosphoranyl thiazine-S-oxides as preursors is reported.Key steps include a Staudinger reaction,an aza-Wittg reactiona d the conversion of a thiazine-S-oxides as precursors is reported.Keysteps include a Staudinger reaction,an aza-Wittig reaction and the conversion of a thiazine-S-oxide into an amino ketone via a [2,3]sigmatropic rearrangement.