Unexpected and facile bridgehead substitution in 5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)-ones

摘要

Condensation of 2,6-diamino-4(3 (H) under bar)-pyrimidinone with 2-cyclohexen-1-one gives a tricyclic product resulting from Michael addition followed by intramolecular hemiaminal formation. A methodology has been developed for reductive removal of the bridgehead hydroxyl group. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 24]