Highly enantioselective reduction of achiral ketones with NaBH_4/Me_3SiCl catalyzed by (S)-#alpha#,#alpha#-diphenylpyrrolidinemethanol

摘要

The reducing agent prepared from sodium borohydride, trimethylsilyl chloride and a catalytic amount of (S)-#alpha#,#alpha#-diphenylpyrrolidinemethanol has been successfully applied to the enantioselective reduction of ketones. The opticaly active secondary alcohols were obtained in excellent enantiomeric excess and almost quantitative cheical yield.