Synthesis of the 2 beta,3 beta-, 2 alpha,3 beta-, 2 beta,3 alpha- and 2 alpha,3 alpha- isomers of 6 beta-hydroxy-3-(p-tolyl)tropane-2-carboxylic acid methyl ester

摘要

6-Hydroxytropanone (8) was synthesized by a Mannich type condensation between acetonedicarboxylic acid, methylamine hydrochloride, and the hydrolysis product of 2,5-dimethoxydihydrofuran and was used as the key intermediate for the synthesis of the four racemic isomers of 6 beta-hydroxy-2-(methoxycarbonyl)-3-(p-tolyl)tropane. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 24]