Carbonylation of 2-Chloro-4,6-dimethoxypyrimidine and 2-(Chloromethyl)-4,6-dimethoxypyrimidine

摘要

The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2-(chloromethyl)pyrimidine with carbon monoxide in the presence of palladium acetate and 1,1'-bis(diphenylphosphino)ferrocene is described. The new process used readily available starting materials and affords the corresponding esters in good yields.