Asymmetric desymmetrization of meso-tetrahydrofuran derivatives by highly enantiotopic selective C-H oxidation

摘要

Asymmetric desymmetrization of meso-tetrahydrofuran derivatives was successfully achieved by Mn-salen catalyzed enantiotopic selective C-H oxidation, giving optically active lactols (up to 90% ee) which serve as useful chiral building blocks for organic synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 27]