FUNCTIONALISED PYRROLIDINONES DERIVED FROM (S)-PYROGLUTAMIC ACID BY CYCLOADDITION REACTIONS

摘要

The alpha,beta-unsaturated bicyclic lactams 3a,c, prepared from (S)-pyroglutamic acid, are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3c has very superior reactivity with several dienes and dipoles under mild reaction conditions. (C) 1997 Elsevier Science Ltd. [References: 40]