5'-O-BENZOYL-2'-KETO-3'-DEOXY-ALPHA-URIDINE - FIRST UNAMBIGUOUS SYNTHESIS, CRYSTAL STRUCTURE AND ITS USE TO ESTABLISH THE ANOMERISATION OF 2'-KETOURIDINES UNDER BASIC CONDITIONS

摘要

5'-O-benzoyl-3'-deoxy-2'-keto-alpha-uridine was characterised unambiguously with the help of crystal structure analysis and provided H-1-NMR data to differentiate it from its B-anomer. We have also established, with the help of the above H-1-NMR data that the earlier reported procedures (ref. 4,5) of synthesising 2'-ketouridine produced a mixture of anomers. [References: 14]