A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

摘要

The stereoselective synthesis of the spiroketal fragment 4a and its C1"-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction. (C) 2002 Elsevier Science Ltd. All rights reserved. [References: 18]