Total Synthesis of R-(+)-Patulolide A and R-(-)-Patulolide B: The Macrolides Isolated from Penicillium urticae Mutant

摘要

The title compounds (2E,11R)-4-oxo-2-dodecen-11-olide, 1 and (2Z,11R)-4-oxo-2-dodecen-11-olide, 2 were synthesised in optically pure forms from a nitroalkane synthon involving a chiral resolution step using goat liver lipase.