Facile Asymmetric Synthesis of #alpha#-Amino Acids Employing Chiral Ligand-Mediated Asymmetric Addition Reactions of Phenyllithium with Imines

摘要

A three-step methodology involving an external chiral ligand-mediated asymmetric addition of phenyllithium to an anisidine imine, oxidative removal of N-PMP goruop, and finally oxidative conversion of the phenyl gorup to a carboxyl group provides a facile synthesis of optically pure #alpha#-amino acid derivatives bearing a bulky #alpha#-substitutent.