Synthesis and analysis the sterically constrained L-glutamine analogues(3S,4R)-3,4-dimethyl-glutamine and (3S,4R)-3,4-dimethyl-L-pyroglutamic acid

摘要

The nonproteingnic amino acids(3S,4R)-3,4-dimethyl-L-pyroglutamic acid and(3S,4R)-3,4-dimethyl-L-glutamine-found in the cyclic depsipetides cappipeltin B, calipeltin A, and papuamide A-were synthesized from a common intermediate derived from L-pyroglutamic acid