Rhodium-catalyzed asymmetric 1,4-addition of alkenylsilanes generated by hydrosilylation of alkynes: a one-pot procedure where a rhodium/(S)-binap complex catalyzes the two successive reactions

摘要

A rhodium complex [Rh((S)-binap)(MeCN)(2)]BF4 (3mol%) catalyzes successively hydrosilylation of 1-alkynes with triethoxysilane and asymmetric 1,4-addition of the resulting alkenylsilanes to cyclic alpha,beta-unsaturated ketones. This one-pot procedure gave high yield of the corresponding 1,4-addition products with over 90% enantioselectivity. (C) 2004 Elsevier Ltd. All rights reserved.