Synthesis and resolution of 2,2-dimethyl-1,3-diphenyl-1,3-propanediol, a new C-2-symmetric and conformationally rigid acyclic diol

摘要

Diastereomerically pure (+)- and (-)-2,2-dimethyl-1,3-diplienyl-1,3-propanediols were synthesized starting from diethyl malonate and resolved through diesters of (-)-camphanic acid and also N-carbethoxy-L-proline. The absolute configuration of the (-)-enantiomer was established by X-ray crystallography. (C) 2002 Elsevier Science Ltd. All rights reserved. [References: 25]