Organocatalytic asymmetric aza-Michael addition of pyrazole to chalcone

摘要

An efficient enantioselective aza-Michael addition of pyrazole to chalcone was established. In the presence of the primary amine derived from cinchona alkaloid and acidic additive, the reactions afforded 1,4-adducts in high yields (up to 98%) with 68-88% ee.