Hypofractionated stereotactic radiotherapy for brain metastases: a dosimetric and treatment efficiency comparison between volumetric modulated arc therapy and intensity modulated radiotherapy.

摘要

A treatment planning comparison study was performed to evaluate the dosimetric characteristic and treatment efficiency of volumetric modulated arc therapy with step-and-shoot intensity modulated radiotherapy (IMRT) for the hypofractionated stereotactic radiotherapy (HFSRT) in patients with multiple brain metastases. CT datasets of 10 patients with two to four brain metastases were selected for the comparison. Three plans were generated for each case: seven-field step-and-shoot IMRT, single (RA1) and double (RA2) arcs with RapidArc technique (RA, Varian Medical System). The prescribed dose was 50 Gy in 10 fractions and plans were all normalized to the mean dose to the PTV. For PTV, plans aim to achieve at least 98% of PTV was covered with the 95% of prescription dose, at least 95% of PTV was encompassed by the prescription dose, and an over-dosage of 110% of the prescription dose was allowed to 5% volume of the PTV. The plans generated using three techniques were clinically acceptable. The target conformity and homogeneity were improved slightly with RA2 compared to IMRT and RA1. The Paddick CI was 0.868 (IMRT), 0.863 (RA1) and 0.895 (RA2), and HI was 7.7 (IMRT), 7.5 (RA1) and 6.5 (RA2), respectively. Compared with IMRT, the maximum dose in RA2 plans to the brainstem, left and right optic nerves, left and right lens was reduced by 1.6 Gy, 6 Gy, 3 Gy, 1.5 Gy, 1.3 Gy, respectively. The percentage of healthy tissue volume receiving 5 Gy was larger with RA1 (56.7%) and RA2 (57.1%) than with IMRT (52.9%), while the percentages of volume receiving 15 Gy and 20 Gy were smaller with RA1 (27.1%, 18.7%) and RA2 (25%, 16.3%) than with IMRT (28.8%, 19.1%). No significant difference was observed between RA1 and RA2. The mean number of MU per fraction of 5 Gy was 1944 +/- 374 (IMRT), 1199 +/- 173 (RA1) and 1387 +/- 186 (RA2), respectively. Compared with IMRT, the MUs were reduced by 36.8% and 27.2% with RA1 and RA2. The pure beam-on time needed per fraction was 6.5 +/- 1.2 min (IMRT), 1.25 min (RA1) and 2.5 min (RA2), respectively. The beam-on time for RA1 and RA2 was approximately 80% and 40% less compared to IMRT. In conclusion, RA, single arc or double arcs, is a feasible technique with highly conformal dose distribution for the HFSRT in patients with oligo brain metastases. Compared with IMRT, RA1 provides similar plan quality, while RA2 achieves slight improvements in PTV coverage and sparing of organs at risk. The treatment efficiency, using less monitor units and shorter treatment delivery time, is the most obvious advantage.