An extremely rare adenocarcinoma arising from a mature cystic teratoma is reported. A 58-year-old woman underwent bilateral salpingo-oophorectomy because of a tumor in each ovary. The right ovarian tumor (solid, 9.6 x 9.6 x 6.3 cm) was a benign thecoma. Histology revealed the left ovarian cystic tumor (multilocular, 6.4 x 4.8 x 2.8 cm) was a mature cystic teratoma containing skin, fatty tissue and respiratory epithelial tissue. In addition, there was a small focal adenocarcinomatous lesion contiguous to the teratomatous ciliated columnar epithelium without stromal invasion (so-called adenocarcinoma in situ) that was suggestive of respiratory epithelium origin. However, goblet cells were present in the glandular structures of the lesion and immunohistochemical staining was segmentally strongly positive for CK20 and uniformly negative for CK7. These results suggested that the adenocarcinomatous lesion had a mucin secretory gastrointestinal phenotype. Further investigation and the collection of more casesis necessary to determine the origin and growth mechanism of adenocarcinoma arising from mature cystic teratoma of the ovary.
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机译：据报道，由成熟的囊性畸胎瘤引起的一种极为罕见的腺癌。一名58岁的妇女因每个卵巢都有肿瘤而接受了双侧输卵管卵巢切除术。右侧卵巢肿瘤（实心，9.6 x 9.6 x 6.3厘米）是良性昏迷。组织学显示左卵巢囊性肿瘤（多眼，6.4 x 4.8 x 2.8 cm）是成熟的囊性畸胎瘤，包含皮肤，脂肪组织和呼吸道上皮组织。此外，还有一个小的局灶性腺癌病变，毗邻无畸形的畸胎瘤纤毛柱状上皮（所谓的原位腺癌），提示呼吸道上皮起源。然而，杯状细胞存在于病变的腺结构中，免疫组织化学染色显示CK20的部分强阳性和CK7的均匀阴性。这些结果表明腺癌病灶具有粘蛋白分泌型胃肠道表型。为了确定由成熟的卵巢囊性畸胎瘤引起的腺癌的起源和生长机制，进一步的研究和收集更多病例是必要的。
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