Towards Synthetic Adrenaline Receptors-Shape-Selective Adrenaline Recognition in Water

摘要

In spite of their key role in signal transduction, the mechanism of action of adrenergic receptors is still poorly understood. We have imitated the postulattd binding patern of the large membrane protein with a small,rationally designed synthetic host molecule. Experimental evidence is presented for the simultaneous operation of electrostatic attraction, hydrogen bonds, #pi# stacking, and hydrophobic binteractions. By virture of this comination of weak atractive forces, adrenaline derivaties in water are boudn wtih high shape selectivity for the slim dopamine skeleton. We think that these findings support the postulated cooperative interplay of noncovalent interactins in the natural receptors. In addition, they provide access to a new type of adrenaline sensor. This may be the first step towards an artificial signal-transductin system.