The evolution of safe, effective filling agents has become a critical step in non-invasive facial rejuvenation. Their combination with other minimally invasive therapies for the skin, such as chemical peels, radiofrequency-based and light-based treatments, has increased the degree of esthetic results and the level of satisfaction for patients and physicians. There have been many discussions theorizing the attributes of the perfect filling agent. We want a product that can be administered safely, conveniently, rapidly, and painlessly and without leaving any traces that it has been applied. We want a product that does not result in any complications and that lasts a long time. The ideal substance should be biocompatible, non-immunogenic, nonresorbable, nonpyogenic, noncarcino-genic, inexpensive, and nonmigratory, with the ability to be stored, shaped, removed, and sterilized easily.1 We have not yet achieved this level of perfection, but the non-animal-derived, stabilized hyaluronic acid products are the current state of the art, fulfilling much of our desired criteria. This article describes our clinical experience in the use of the currently available hyaluronic acid products for oculofacial rejuvenation.
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