Merging organocatalysis with an indium(III)-mediated process: A stereoselective α-alkylation of aldehydes with allylic alcohols

摘要

Curiosity killed the CAT..ions! The use of stabilized cationic intermediates can be considered as a new frontier in the development of stereoselective reactions. An organocatalytic procedure mediated by the MacMillan imidazolidinone catalyst was coupled with an InBr_(3-)mediated process for the development of a novel stereoselective allylation reaction of aldehydes. Up to 98 % ee and up to 5:1 d.r. were obtained in the process.