Comparison of Survival of Patients with Heart and Lung Transplants on Peritoneal Dialysis and Hemodialysis

摘要

Organ transplantation is the most successful treatment available for patients with failure of the kidney, heart, and lungs. With the advent of improved surgical techniques and the availability of potent immunosuppressant drugs like cal-cineurin inhibitors in the last 3 decades, patients with heart and lung transplants are living longer with a functioning graft. However, one of the most severe side effects of the use of calcineurininhibitortherapyisthe development of chronic kidney disease (CKD) leading to end-stage renal disease (ESRD) (1,2). In the seminal paper by Ojo et al. in 2003, the incidences of advanced CKD (defined as estimated glomerular filtration rate < 30 mL/min/1.73m2 body surface area) at 5 years after transplant of heart, lung, and combined heart and lung were 10.9, 15.8, and 6.9%, respectively (1). Twenty-nine percent of those who develop CKD after transplantation progressed to ESRD.