There are an estimated 782,000 diagnoses and 746,000 deaths attributed to primary liver cancer annually.1 The liver is also the second most common site for metastatic spread, with significantly more patients suffering from liver metastases than primary cancer,Ultrasound is the most commonly used imaging modality of the liver.3 It is inexpensive, portable, nonionizing and has an excellent safety record.4-5 Traditional gray-scale and color Doppler ultrasound imaging have inherent limitations. First, detection of FLLs is complicated by similar echoge-nicity of the lesion and the surrounding liver parenchyma. Second, accurate characterization of FLLs is problematic with different pathologic lesions having overlapping or nondiscrete gray-scale imaging features.
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