High pressure, high temperature reactions in continuous flow Merging discovery and process chemistry

摘要

The application of flow reactors to increase the parameter space of organic chemistry reactions in current laboratory practice is explored. Using examples such as DielsAlder reactions, Knorr reactions and others, the paper demonstrates the advantages of flow reactors operating in a parameter space up to 350°C (662°F) and 200 bar (2900 psij, sometimes under supercritical conditions, and in some cases without catalysts. The flow reactors described in the paper offer for the first time an alternative solution to the microwave batch scale up.