Synthesis and Biological Evaluation of Some New Fused Heterobicyclic Derivatives Containing 1,2,4-Triazolo/1,2,4-Triazinopyridinone Moieties

摘要

Syntheses of fused lieterobicyclic systems containing l,2,4-triazolo/l,2,4-triazinopyridinone moieties were accomplished by heterocyclizatkm of 4-(4-chlorophenyl)-l,6-diamino-2-oxo-l,2-dihydropyridine-3,5-dicarbonitrile (III) or 6-amino-4-(4-chlorophenyl)-2-oxo-l-(5,6-diphenyl-l,2,4-triazin-3-ylamino)-l,2-dihydropyridine-3,5-dicarbonitrile (XII) with a,/3-bifunctional oxygen and halooxo compounds in different media in order to establish a relation between structure and their activities. Compounds III and XII which contain 1,2-biamino group are more favoured to the ring-closure reactions. Structure assignments of new products have been established on the basis of elemental analysis and spectral data. The antimicrobial activity of the products has been also evaluated where some compounds showed a better activity against selected tested microbes in comparison with control.