New Insight into Effects of beta-Blockers on Arterial Functions

摘要

The effects of B-blockers on arterial properties are not well investigated. In our recent study, we compared the effects of the two B-blockers celiprolol and bisoprolol on blood pressure, baroreflex sensitivity (BRS), flow-mediated vasodilatation, and vascular stiffness. We found that bisoprolol achieved a greater reduction in the pulse rate and improved BRS and vascular stiffness, whereas celiprolol reduced the central blood pressure level. In this review, the mechanisms of different types of B-blockers and their effects on arteries are discussed, and the appropriate use of {3-blockers in hypertensive subjects will be proposed.