Role of tie D1 receptor for tie dopamine agonist-Induced one-trial beiavloral sensitization of preweanling rats

摘要

Rationale The neural mechanisms mediating the ontogeny of behavioral sensitization are poorly understood. Objective The purpose of the present study was to determine the role of the Dl receptor for the induction of dopamine agonist-induced behavioral sensitization during the preweanling period.Methods In the first experiment, the early ontogeny of R-propylnorapomorphine (NPA)-induced behavioral sensitization was examined by pretreating male and female rats with saline or NPA (0.5, 1, or 2 mg/kg, intraperitoneally (IP)) before placement in activity chambers on postnatal day (PD) 12, 16, 20, or 24. One day later, rats were tested with lower doses of NPA and the occurrence of locomotor sensitization was determined.