Association of the dopamine D3 receptor Ser9Gly and of the serotonin 2C receptor gene polymorphisms with tardive dyskinesia in Greeks with chronic schizophrenic disorder.

摘要

Association between tardive dyskinesia (TD) and Ser9Gly of the dopamine D_3 receptor (DRD_3) (Steen et a/., 1997; Woo et al., 2002) and the serotonin 2G receptor (5-HT2C) genes polymorphisms has been reported in patients with schizophrenic disorder (Segman et al, 2000; Zhang et al., 2002). We investigated the presence of two polymorphisms of the promoter region of 5-HT2G receptor gene - 759C/T and -697G/G with TD as well as the association of the Ser9C/y polymorphism of the DRD_3 gene with TD.