Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo

摘要

Over-nutrition and consumption of high-fat diets are associated with obesity-related cardiomyopathy and increased risk for heart failure [1,2]. In obesity, the elevated plasma free fatty acid (FFA) concentration induces an increase in myocardial fatty acid (FA) uptake and oxidation [3]. Despite the increase in FA oxidation, the excessive availability of FA may lead to an imbalance between FA uptake and oxidation, resulting in an increased deposition of potentially toxic lipids in the heart [4,5]. Myocardial lipid accumulation has been implicated in the development of cardiomyopathy through a number of pathways, including lipid-induced apoptosis [6] and fibrosis [7,8].