Comparison of antimicrobial activity between lactoferricin B 15 derivative and antibiotics

摘要

The cationic antimicrobial peptide lactoferricin B15 (LfcinB15, FKCWRWQWRWKKLGA), was synthesized by chemical method. In vitro susceptibilities of LfcinB15 and four antibiotics for clinical useage (benzylpenicillin, chlorte-tracycline hydrochloride, streptomycin, doxycycline) were evaluated against several gram-positive and gram-negative bacteria and against Pichia pastoris GS115 using a modified microtitre broth dilution method by the Hancock laboratory. The tested peptide showed different antimicrobial activity against 6 species of microorganisms. Obviously, the gram-positive bacteria are much more sensitive to LfcinB15 than