Response to 'concerns about the statistical methodology described in the 'Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11105 pregnancies with mixed risk factors''

摘要

Thanks a lot for your comments on the publication by Dan et al} We have read carefully through your comments and responded as follows:Firstly, the statistical methodology by Jiang et al.2 that we described is the original version of our bioinformatics analysis approach. For your comments on cell-free fetal DNA (cff-DNA) concentration, we agree with you that the cff-DNA concentration is of significance to non-invasive prenatal test (NIPT). Therefore, we do demonstrate the approach to estimate cff-DNA concentration in this article. There was a typographical error in the published formula in the article by Jiang et al where the subscript T should be 'X'.