A study of the precipitation polymerization of bisphenol A-imprinted polymer microspheres and their application in solid-phase extraction

摘要

Bisphenol A (BPA) imprinted polymer microspheres were prepared by precipitation polymerization and utilized as sorbents for packing common solid phase extraction columns. In order to find out the influence of solvent on the size and structure of the microspheres, different ratios of toluene to acetonitrile (0/100, 15/85, 25/75, 30/70, v/v) were used as solvents in the precursor and mainly discussed. Particle size, surface area, and pore volume of BPA-imprinted particles increased with the ratios of toluene in the precursor. The selectivity of the BPA-imprinted particles was evaluated toward structure analogs such as diethylstilbestrol and phenol. Microspheres as prepared were then utilized as sorbents for solid-phase extraction of BPA from urine, with recoveries of 94.63 ± 2.85%.