Synthesis and properties of polyurethanes containing phosphatidylcholine analogues in the main chains and long-chain alkyl groups in the side chains

摘要

New phospholipid polyurethanes containing phosphatidylcholine analogues in the main chains and octyl or oleyl groups in the side chains were synthesized by the addition polymerization of diols, bis[2-(2-hydroxyethyldimethylammonio)ethyl]2-octyl-1,3- propanediphosphate or bis[2-(2-hydroxyethyldimethylammonio)ethyl]2-oleyl-1,3- propanediphosphate, with diisocyanates such as 4,4'-diphenylmethane diisocyanate (MDI), hexamethylene diisocyanate (HDI), and 2,4-tolylene diisocyanate (TDI). The new phospholipid diols and polyurethanes were characterized by their IR and H-1-NMR spectral data and elemental analysis. The new phospholipid polyurethanes exhibit common polyelectrolyte viscosity behaviours revealed by viscosity measurements. Moreover, pi-A isotherms for these polyurethanes were also prepared.