Synthesis and anti-Candida activity of copper(II) and manganese(II) carboxylate complexes X-ray crystal structures of [Cu(sal)(bipy)] centre dot C_2H_5OH centre do tH_2O and [Cu(norb)(phen)_2] centre dot 6.5H_2O (sa1H_2 = salicylic acid; norbH_2 = ci

摘要

The copper(II) complexes [Cu(salH)_2(H_2O_2)] centre dot 0.5H_2O (1) (salH_2 = salicylic acid) and [Cu_2(asp)_4] centre dot 3H_2O (8) {aspH = acetylsalicylic acid (aspirin)} both react with imidazole (imid), 1, 10-phenanthroline (phen) and 2, 2'-bipyridine (bipy) giving [Cu(sal)(imid)] (2), [Cu(sal)(phen)] (3) and [Cu(sal)(bipy)] centre dot C_2H_5OH centre dot H_2O (4). CuCl_2centre dot2H_2O reacts with cis-5-norbornene-endo-2, 3-dicarboxylic acid (norbH_2) and NaOH giving [Cu(norb)]centre dotH_2O (9). Complexes 4 and 9 were crystallographically characterised. The above complexes, together with the related manganese(II) complexes, [Mn_2(salH)_4(H_2O)_4] (5), [Mn(salH)_2(phen)] (6), [Mn(salH)_2(bipy)] centre dot H_2O (7), [Mn(norb)H_2O] (11) and [Mn(norb)(phen)_2] centre dot C_2H_5OH centre dot H_2O (12) and also the metal-free ligands were screened for their ability to inhibit the growth of the pathogenic yeast Candida albicans. 1, 0-Phenanthroline and the phenanthroline complexes 6, 10b and 12 exhibited high anti-Candida activity with the manganese complexes 6 and 12 being the most potent.