PharmGKB summary: Very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6

摘要

Human cytochrome P-450 (CYP-450), family 2, subfamily A, polypeptide 6 (CYP2A6) is a monooxygenase enzyme that metabolizes xenobiotic compounds and activates toxins [1-3]. In this review, we focus on the effect of genetic variants on the role of CYP2A6 in drug metabolism, and provide a pharmacogenomic overview of CYP2A6 in humans. This Very Important Pharmacogene summary is available with interactive links to gene variants, haplotypes, and drugs on the PharmGKB website http:llpharmgkb.org/viplPA121 [4].