Preincisional Versus Postincisional Administration of Parecoxib in Colorectal Surgery: Effect on Postoperative Pain Control and Cytokine Response. A Randomized Clinical Trial

摘要

Background Preincisional pain management aims at reducing pain and inflammatory response. We investigated whether preincisional parecoxib administration reduces pain, opioid requirements, and cytokine production after surgery for colonic cancer.