酸素付加能を有する振動流型人工心臓の開発とその牛血実験

摘要

人工心臓は近年目覚ましく発展しており，血流を生rnみ出すポンプ機構としてさまざまな方式が提案されてrnいる．心臓や冠動脈手術の際には，血液ポンプによrnり血流を生み出すとともに，人工肺を用いて血液中のrnガス交換を行う．このような機能を有する装置全体をrn人工心肺装置と呼び，すでに欠くことのできない医療rn機器となっている．%We had developed the vibrating flow pump (VFP) for left ventricular assist device based on the fluid dynamical analysis and the animal tests. The main advantages of VFP were generating the oscillated blood flow and having simple mechanical structure. In this study, we constructed an experimental apparatus for a prototype artificial heart and lung by means of installing hollow fibers into the vibrating tube in the VFP. The characteristics of gas exchange were investigated both by experiment using bovine blood and by numerical analysis. The unsteady, incompressible, and axisymmetric Navier-Stokes equations and diffusion equation were solved based on finite difference technique. In the prototype VFP, the effect of the oscillated flow on the gas exchange was relatively small in the range of Reynolds number of O (1) ～ O (1 000). Comparing experimental and numerical results, we discussed the validity of the numerical analysis and predicted the characteristics of the VFP. The basic design data of VFP installing hollow fibers were accumulated for the artificial heart and lung.