MICROPARTICLES OF HYDROGEL TYPE BASED ON CARBOXYMETHYLCELLULOSE AND GELATIN FOR CONTROLLED RELEASE OF WATER SOLUBLE DRUGS

摘要

The aim of this work is obtaining and characterizing Interpenetrating Network hydrogel based microparticles. They are elaborated by the inverse emulsion co-crosslinking reaction of carboxymethylcellulose and gelatin with epichlorohydrin. The influence of parameters related with the particles elaboration process (ratio of polymers in the mixture, ratio between polymer mixture and crosslinking agent, concentration of polymer solution, duration of crosslmking reaction, stirring intensity...) on their composition, size and swelling ability was studied. Obtained microparticles fulfill the requirements for biomaterials: to be formed from biocompatible polymers, the acute toxicity value (DL_(50)) is high enough to consider these materials as weakly toxic (hence able to be introduced within the organism). They are able to include and release drugs in a controlled way and tests carried out with cefotaxime loaded microparticles demonstrate their antibacterial activity.